Please discuss the risks and review the Medication Guide with patients before they take VENCLEXTA (venetoclax tablets).

Advise patients 1:

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To take VENCLEXTA exactly as prescribed and not to change their dose or to stop taking VENCLEXTA unless they are told to do so by their doctor.

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To be adequately hydrated every day when taking VENCLEXTA to reduce the risk of TLS. The recommended volume is 6 to 8 glasses (approximately 56 ounces total) of water each day. Patients should drink water starting 2 days before and on the day of the first dose, and every time the dose is increased.

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Of the importance of keeping scheduled appointments for blood work or other laboratory tests.

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To take VENCLEXTA orally once daily with a meal and water at approximately the same time each day.

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That VENCLEXTA tablets should be swallowed whole and not chewed, crushed, or broken.

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To avoid consuming grapefruit products, Seville oranges, and starfruit during treatment with VENCLEXTA.