Efficacy was established based on the rate of CR and the duration of CR.
AML=acute myeloid leukemia; CLcr=creatinine
clearance; ECOG=Eastern Cooperative Oncology Group; IV=intravenous;
QD=once a day.
*All patients received TLS prophylaxis and were
hospitalized for monitoring during the ramp-up.
CR was defined as absolute neutrophil count (ANC)
>1,000/microliter, platelets >100,000/microliter, red blood
cell transfusion independence, and bone marrow with <5% blasts.
Absence of circulating blasts and blasts with Auer rods; absence of
extramedullary disease.
CRh was defined as <5% of blasts in the bone
marrow, no evidence of disease, and partial recovery of peripheral
blood counts (platelets >50,000/microliter and ANC >500/microliter).