The fixed duration of VENCLEXTA-based regimens offers a chance for a treatment-free period, which means patients can return to life without a daily reminder of their treatment and disease. A defined end to treatment encourages compliance and optimized clinical outcomes. ^1,18,19 

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Dosing schedule

Instructions for taking VENCLEXTA

Instructions for taking VENCLEXTA ¹

• Take VENCLEXTA tablets exactly as they are prescribed and not to change or interrupt their dose unless they are told to do so by their doctor
• Take VENCLEXTA orally once daily, at approximately the same time each day, according to their healthcare provider's instructions, and that the tablets should be swallowed whole with a meal and water without being chewed, crushed, or broken
  
• Be adequately hydrated every day they take VENCLEXTA to reduce the risk of TLS. The recommended volume is 6-8 glasses (~56 ounces) of water every day starting 2 days before the first dose and throughout the ramp-up phase, especially the first day of each dose increase
• Attend every scheduled appointment for blood work and other laboratory

• Crush, chew, or break their VENCLEXTA tablets
• Remove their VENCLEXTA tablets from the original packaging during the first 4 weeks of treatment, and do not transfer them to a different container
• Take an additional dose if vomiting occurs after taking VENCLEXTA. They should take the next dose at the usual time the following day
• Consume grapefruit products, Seville oranges, or starfruit during treatment with VENCLEXTA

• Within 8 hours of the time it is usually taken, the patient should take the missed dose right away and take the next dose as usual
• By more than 8 hours, the patient should not take the missed dose and should take the next dose at the usual time