- To gradually reduce tumor burden (debulk) and decrease the risk
of TLS, start with the 5-week VENCLEXTA dose ramp-up
*24 months from Cycle 1, Day 1 of rituximab.
IV=intravenous; TLS=tumor lysis syndrome.
Dose information
VENCLEXTA 1
- The VENCLEXTA starting dose is 20 mg once daily for 7 days,
ramping up weekly to 50 mg, 100 mg, 200 mg, and finally 400 mg once
daily
- After ramp-up, VENCLEXTA should be taken at the
recommended daily dose for 24 months
RITUXIMAB
- Start rituximab 375 mg/m2 after the patient has
received the 400-mg dose of VENCLEXTA for 7 days
- Administer
rituximab 500 mg/m2 on Day 1 of each subsequent cycle,
for a total of 6 cycles
Note: VENCLEXTA may also be given as monotherapy until disease
progression or unacceptable toxicity. Please see the full Prescribing Information for more information.