The 5-week ramp-up dosing schedule is designed to gradually reduce tumor burden (debulk) and decrease the risk of tumor lysis syndrome (TLS)

  • The starting dose is 20 mg once daily for 7 days, ramping weekly to 50 mg, 100 mg, 200 mg, and finally 400 mg once daily 
  • The CLL/SLL Starting Pack provides color-coded weekly wallet blister packs for the first 4 weeks according to the ramp-up schedule
  • The recommended daily dose of 400 mg is supplied as 100 mg tablets
  • Instruct patients to take VENCLEXTA tablets with a meal and water at approximately the same time each day; tablets should be swallowed whole and not chewed, crushed, or broken prior to swallowing
  • After ramp-up, VENCLEXTA should be taken at the recommended daily dose for 24 months 
  • Start rituximab administration after the patient has completed the 5-week ramp-up schedule with VENCLEXTA and has received the 400 mg dose of VENCLEXTA for 7 days
  • For information regarding VENCLEXTA dose modifications for TLS, non-hematologic, and hematologic toxicities, please see section 2.3 of the VENCLEXTA full Prescribing Information

VEN+R dosing schedule

Instructions for taking VENCLEXTA

In case of a missed dose

If a patient misses a dose within 8 hours of the time it is usually taken
  • The patient should take the missed dose right away and take the next dose as usual.
If a patient misses a dose by more than 8 hours
  • The patient should not take the missed dose and should take the next dose at the usual time.
If a patient vomits following dosing
  • No additional dose should be taken that day.
  • The next dose should be taken at the usual time the following day.