The 5-week ramp-up dosing schedule is designed to gradually reduce tumor burden (debulk) and decrease the risk of tumor lysis syndrome (TLS) 1

  • The VENCLEXTA starting dose is 20 mg once daily for 7 days, ramping weekly to 50 mg, 100 mg, 200 mg, and finally 400 mg once daily
  • Start rituximab administration after the patient has completed the 5-week ramp-up schedule with VENCLEXTA and has received the 400 mg dose of VENCLEXTA for 7 days
  • After ramp-up, VENCLEXTA should be taken at the recommended daily dose for 24 months
  • The CLL/SLL Starting Pack provides color-coded weekly wallet blister packs for the first 4 weeks, according to the ramp-up schedule
  • The recommended daily dose of 400 mg is supplied as 100-mg tablets
  • Instruct patients to take VENCLEXTA tablets with a meal and water at approximately the same time each day; tablets should be swallowed whole and not chewed, crushed, or broken prior to swallowing
  • For information regarding VENCLEXTA dose modifications for TLS, non-hematologic, and hematologic toxicities, please see section 2.3 of the VENCLEXTA full Prescribing Information

*24 months from Cycle 1, Day 1 of rituximab; please see Dosing and Administration in the full Prescribing Information.
Start rituximab after patient has received the 400-mg dose of VENCLEXTA for 7 days.

R/R=relapsed/refractory; SLL=small lymphocytic lymphoma; IV=intravenous

Instructions for taking VENCLEXTA